HORDB

ID: hor002620
Uniprot ID: O01970
Protein name: NLP-12
Gene name: nlp-12
Organism: Caenorhabditis elegans
Family: NA
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0031739 cholecystokinin receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0060756 foraging behavior
GO CC: GO:0005615 extracellular space; GO:0043005 neuron projection; GO:0043025 neuronal cell body

Sequence: DGYRPLQF
Length: 8
Propeptide: MLRHHSCALLMLILVFVEVFATQSPTFDRQDRDYRPLQFGKRDGYRPLQFGKRDYRPLQFGKRSSGSSGPVVLEPIWEWQ
Signal peptide: MLRHHSCALLMLILVFVEVFA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002620_AF2.pdb

hor002620_ESM.pdb

Mass:	112014	Formula:	C46H66N12O13
Absent amino acids:	ACEHIKMNSTVW	Common amino acids:	DFGLPQRY
pI:	6.34	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	2
Hydrophobicity:	-102.5	Boman Index:	-2048
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	3240	Extinction Coefficient cystines:	1490
Absorbance 280nm:	212.86

PubMed ID: 20013198
Title: Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans